Brand(s):
- Alfacal
Manufacturer:
- Macleods
Disease(s):
- Osteoporosis / Hypocalcemia / Hypophosphatemia / Osteodystrophy / Rickets / Prophylaxis / Secondary Hyperparathyroidism / Tetany / Vitamin D Deficiency /
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One-alpha
alfacalcidol
Alfacalcidol, a vital metabolite of vitamin D, plays a crucial role in managing calcium balance and bone metabolism. Unlike plain vitamin D, alfacalcidol bypasses the regulatory constraints of the negative feedback mechanism, offering a more reliable and effective therapeutic option for osteoporosis.
Activated by the enzyme 25-hydroxylase in the liver and osteoblasts, alfacalcidol exerts a range of pleiotropic effects, influencing various tissues and organs. These include the gut, bone, parathyroid glands, muscle, and brain. Its primary mechanism of action in bone, however, remains an intriguing enigma.
Alfacalcidol operates through a multifaceted mechanism, impacting multiple aspects of calcium homeostasis. It augments intestinal calcium absorption, promoting efficient calcium uptake from the digestive tract. Simultaneously, it boosts urinary calcium excretion, preventing hypercalcemia and ensuring proper calcium balance. Moreover, alfacalcidol reduces parathyroid hormone (PTH) secretion, a key player in calcium regulation. By lowering PTH levels, it helps maintain healthy calcium levels and prevents excessive bone resorption.
Furthermore, alfacalcidol exhibits unique properties that distinguish it from its parent compound, vitamin D. Its activation pathway bypasses the final kidney activation step, eliminating the influence of the negative feedback mechanism. This unique attribute makes alfacalcidol more predictable and reliable in maintaining stable calcium levels and promoting bone health.
Despite its widespread use in osteoporosis treatment, a complete understanding of alfacalcidol's mechanism of action in bone remains elusive. Nevertheless, its proven efficacy in managing calcium balance and promoting bone health has established it as a valuable therapeutic agent in the fight against osteoporosis.
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| Package | Per pill | Price | Savings | Order |
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180 capsules
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$ 0.80
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$ 143.95 $ 0.80 Per pill
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$ 155.75
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120 capsules
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$ 0.90
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$ 107.95 $ 0.90 Per pill
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$ 91.85
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90 capsules
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$ 1.00
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$ 89.95 $ 1.00 Per pill
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$ 59.90
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60 capsules
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$ 1.25
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$ 74.95 $ 1.25 Per pill
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$ 24.95
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30 capsules
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$ 1.67
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$ 49.95 $ 1.67 Per pill
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| Package | Per pill | Price | Savings | Order |
|---|---|---|---|---|
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180 capsules
Free AirMail shipping
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$ 1.00
|
$ 179.95 $ 1.00 Per pill
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$ 137.75
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120 capsules
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$ 1.10
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$ 131.95 $ 1.10 Per pill
|
$ 79.85
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90 capsules
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$ 1.20
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$ 107.95 $ 1.20 Per pill
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$ 50.90
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60 capsules
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$ 1.35
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$ 80.95 $ 1.35 Per pill
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$ 24.95
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30 capsules
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$ 1.77
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$ 52.95 $ 1.77 Per pill
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Brand(s):
- Alfacal
Manufacturer:
- Macleods
Disease(s):
- Osteoporosis / Hypocalcemia / Hypophosphatemia / Osteodystrophy / Rickets / Prophylaxis / Secondary Hyperparathyroidism / Tetany / Vitamin D Deficiency /
Active Ingredient
Alfacalcidol
What is Alfacalcidol?
Alfacalcidol is a synthetic form of vitamin D that is used to treat a variety of calcium metabolism disorders. It is a metabolite of vitamin D and is activated in the liver and kidneys to produce calcitriol, the active form of vitamin D.
What are the Indications for Alfacalcidol?
Alfacalcidol is indicated for the treatment of:
- Renal osteodystrophy
- Hyperparathyroidism (with bone disease)
- Hypoparathyroidism
- Neonatal hypocalcemia
- Nutritional and malabsorptive rickets and osteomalacia
- Pseudo-deficiency (D-dependent) rickets and osteomalacia
- Hypophosphatemic vitamin D-resistant rickets and osteomalacia
How Should I Take Alfacalcidol?
Alfacalcidol is administered orally in capsule form. It should be taken once daily with food to improve absorption.
What are the Contraindications for Alfacalcidol?
Alfacalcidol is contraindicated in patients with:
- Hypersensitivity to alfacalcidol or any of the excipients in the capsule.
- Hypercalcemia
- Metastatic calcification
What are the Warnings and Precautions for Alfacalcidol?
Alfacalcidol should be used with caution in patients with:
- Renal impairment
- Hepatic impairment
- Hypertension
- Cardiac arrhythmias
- Sarcoidosis
- Pregnancy
- Breastfeeding
What are the Possible Side Effects of Alfacalcidol?
The most common side effects of alfacalcidol include:
- Hypercalcemia
- Nausea
- Vomiting
- Diarrhea
- Headache
- Dizziness
- Fatigue
- Muscle pain
- Bone pain
What is the Dosage of Alfacalcidol?
The recommended starting dose of alfacalcidol is 1 mcg per day. The dose may be increased gradually as needed to a maximum of 2 mcg per day.
How to Store Alfacalcidol
Alfacalcidol should be stored at room temperature (25°C) in a tightly closed container.
Can I Buy Alfacalcidol Online?
Yes, you can buy Alfacalcidol online from our pharmacy. We offer a wide range of Alfacalcidol products from trusted manufacturers at competitive prices.
What Payment Methods Do You Accept?
We accept all major credit cards, as well as Bitcoin and other cryptocurrencies.
Do You Ship Internationally?
Yes, we ship internationally to most countries. Shipping costs vary depending on the country of destination.
How Can I Track My Order?
You can track your order online using the tracking number provided in your shipping confirmation email.
What is Your Return Policy?
We offer a 30-day money-back guarantee on all products. If you are not satisfied with your purchase, you can return it for a full refund.
Frequently Asked Questions About Alfacalcidol
- What is Alfacalcidol?
- Alfacalcidol is a synthetic form of vitamin D that is used to treat a variety of calcium metabolism disorders.
- What are the Indications for Alfacalcidol?
- Alfacalcidol is indicated for the treatment of renal osteodystrophy, hyperparathyroidism with bone disease, hypoparathyroidism, neonatal hypocalcemia, nutritional and malabsorptive rickets and osteomalacia, pseudo-deficiency (D-dependent) rickets and osteomalacia, and hypophosphatemic vitamin D-resistant rickets and osteomalacia.
- How Should I Take Alfacalcidol?
- Alfacalcidol is administered orally in capsule form. It should be taken once daily with food to improve absorption.
- What are the Contraindications for Alfacalcidol?
- Alfacalcidol is contraindicated in patients with hypersensitivity to alfacalcidol or any of the excipients in the capsule, hypercalcemia, and metastatic calcification.
- What are the Warnings and Precautions for Alfacalcidol?
- Alfacalcidol should be used with caution in patients with renal impairment, hepatic impairment, hypertension, cardiac arrhythmias, sarcoidosis, pregnancy, and breastfeeding.
- What are the Possible Side Effects of Alfacalcidol?
- The most common side effects of alfacalcidol include hypercalcemia, nausea, vomiting, diarrhea, headache, dizziness, fatigue, muscle pain, and bone pain.
- What is the Dosage of Alfacalcidol?
- The recommended starting dose of alfacalcidol is 1 mcg per day. The dose may be increased gradually as needed to a maximum of 2 mcg per day.
- How to Store Alfacalcidol
- Alfacalcidol should be stored at room temperature (25°C) in a tightly closed container.
Reviews
March 8, 2023
This product is amazing! I have been taking it for a few months now and my calcium levels have improved significantly. I no longer experience the muscle pain and bone pain that I used to.
February 14, 2023
This product has helped me manage my calcium levels. I have noticed a decrease in my muscle pain and bone pain. However, I have experienced some side effects, such as nausea and vomiting.
January 10, 2023
This product has not been as effective as I had hoped. I have not seen a significant improvement in my calcium levels and I still experience muscle and bone pain.
