Zestril, also known generically as lisinopril, is a versatile medication primarily employed in the management of cardiovascular conditions. Its therapeutic applications encompass: 1. Hypertension Management: - Zestril plays a crucial role in reducing high blood pressure, either as a standalone treatment or in combination with other antihypertensive medications. - By effectively lowering blood pressure, Zestril helps diminish the strain on the heart and blood vessels, thereby reducing the risk of cardiovascular complications such as stroke, heart attack, and kidney disease. 2. Heart Failure Management: - Zestril is widely used to manage heart failure, a condition where the heart struggles to pump blood efficiently. - It acts by dilating blood vessels, reducing the workload of the heart and improving its pumping capacity. - Zestril's vasodilatory effect eases the strain on the heart, leading to improved symptoms, enhanced exercise tolerance, and a reduced risk of hospitalization due to heart failure. 3. Post-Heart Attack Care: - Zestril is also employed to improve survival rates and overall outcomes in patients who have suffered a heart attack (myocardial infarction). - Administered soon after a heart attack, Zestril aids in preserving heart function, preventing further damage, and reducing the likelihood of recurrent cardiac events. - It achieves this by lowering blood pressure, improving blood flow to the heart, and inhibiting the remodeling of heart tissue, which can lead to complications. Zestril's effectiveness in treating these cardiovascular conditions stems from its ability to inhibit angiotensin-converting enzyme (ACE), a key enzyme involved in regulating blood pressure. By blocking ACE, Zestril prevents the formation of angiotensin II, a potent vasoconstrictor that narrows blood vessels. This inhibitory action results in the relaxation of blood vessels, reduced blood pressure, and improved blood flow. Zestril is generally well-tolerated, with common side effects including dizziness, headache, and fatigue. It is typically administered orally once or twice daily, and the dosage is adjusted based on individual patient needs and response. Overall, Zestril is a valuable medication in the armamentarium of cardiovascular therapies, effectively managing high blood pressure, alleviating heart failure symptoms, and improving survival outcomes after a heart attack. more