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Sildenafil: Important Information & Usage Guidelines

Sildenafil is a medication primarily used to treat erectile dysfunction (ED) in men and pulmonary arterial hypertension (PAH). Understanding how to use this medicine safely and effectively is crucial. This comprehensive guide provides essential information, including precautions, dosage, potential side effects, and drug interactions.

What should I tell my health care provider before I take this medicine?

Before starting sildenafil, inform your healthcare provider about all your medical conditions, especially if you have:

  • Eye or vision problems, including retinitis pigmentosa (a rare inherited eye disease)
  • Heart disease, angina, high or low blood pressure, a history of heart attack, or other heart problems
  • Kidney disease
  • Liver disease
  • Stroke
  • Any unusual or allergic reaction to sildenafil, other medicines, foods, dyes, or preservatives
  • Deformity of the penis (e.g., Peyronie's disease)
  • A history of bleeding disorders
  • Stomach ulcers
  • Conditions that may increase the risk of priapism (prolonged erection), such as sickle cell anemia, multiple myeloma, or leukemia

How should I use this medicine?

Take sildenafil exactly as prescribed by your doctor. Here are some important guidelines:

  • Take this medicine by mouth with a glass of water.
  • Follow the directions on the prescription label carefully.
  • For erectile dysfunction, the dose is usually taken 1 hour before sexual activity, but it can be taken from 30 minutes to 4 hours before.
  • Do not take the dose more than once per day.
  • Do not take your medicine more often than directed.

Overdosage: If you think you have taken too much of this medicine, contact a poison control center or emergency room at once.

What if I miss a dose?

This does not apply for sildenafil used for erectile dysfunction, as it's taken on demand before sexual activity. Do not take double or extra doses.

What may interact with this medicine?

Sildenafil can interact with several medications, potentially causing serious side effects. Do not take this medicine with any of the following medications:

  • Cisapride
  • Methscopolamine nitrate
  • Nitrates such as amyl nitrite, isosorbide dinitrate, isosorbide mononitrate, nitroglycerin (used to treat angina)
  • Nitroprusside
  • Other sildenafil products or other PDE5 inhibitors (like tadalafil or vardenafil)
  • Riociguat (used to treat pulmonary hypertension)

This medicine may also interact with the following medications:

  • Alpha-blockers (used to treat high blood pressure or prostate problems)
  • Certain drugs for high blood pressure
  • Certain drugs for the treatment of HIV infection or AIDS
  • Certain drugs used for fungal or yeast infections, like fluconazole, itraconazole, ketoconazole, and voriconazole
  • Cimetidine
  • Erythromycin
  • Rifampin

This list may not describe all possible interactions. Give your healthcare provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also, tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

While taking sildenafil, be aware of the following:

  • If you notice any changes in your vision while taking this drug, call your doctor or health care professional as soon as possible.
  • Call your health care provider right away if you have any change in vision.
  • Contact your doctor or health care professional right away if the erection lasts longer than 4 hours or if it becomes painful. This may be a sign of a serious problem and must be treated right away to prevent permanent damage.
  • If you experience symptoms of nausea, dizziness, chest pain, or arm pain upon initiation of sexual activity after taking this medicine, you should refrain from further activity and call your doctor or health care professional as soon as possible.
  • Using this medicine does not protect you or your partner against HIV infection (the virus that causes AIDS) or other sexually transmitted diseases. Always practice safe sex.
  • Sildenafil may cause dizziness or lightheadedness. Avoid driving or operating machinery until you know how this medicine affects you.
  • Limit alcohol consumption, as it can worsen side effects.

What side effects may I notice from receiving this medicine?

Possible side effects of sildenafil include:

Side effects that you should report to your doctor or health care professional as soon as possible:

  • Allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • Breathing problems
  • Changes in hearing, ringing in the ears
  • Changes in vision, blurred vision, trouble telling blue from green color
  • Chest pain
  • Fast, irregular heartbeat
  • Men: prolonged or painful erection (lasting more than 4 hours)
  • Seizures
  • Sudden decrease or loss of vision

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • Diarrhea
  • Flushing
  • Headache
  • Indigestion
  • Stuffy or runny nose

Where should I keep my medicine?

Proper storage of sildenafil is important:

  • Keep out of reach of children.
  • Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F).
  • Protect from moisture and light.
  • Throw away any unused medicine after the expiration date.

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Sildenafil for Pulmonary Arterial Hypertension (PAH)

Sildenafil is also used to treat pulmonary arterial hypertension (PAH). Consult your doctor before using Sildenafil for any other purpose.

Sildenafil FAQs

What is Sildenafil used for?

Sildenafil is primarily used to treat erectile dysfunction (ED) in men and pulmonary arterial hypertension (PAH).

How quickly does Sildenafil work?

For ED, Sildenafil typically starts working within 30-60 minutes after taking it. Its effectiveness can be influenced by food intake and individual metabolism.

How long does Sildenafil last?

The effects of Sildenafil usually last for about 4-5 hours.

Can women take Sildenafil?

While Sildenafil is primarily prescribed for men, it can be prescribed off-label to women for certain conditions, such as pulmonary hypertension. Consult a healthcare professional for guidance.

What are the common side effects of Sildenafil?

Common side effects include headache, flushing, stuffy nose, and indigestion. Serious side effects are rare but can include vision changes and priapism.

Can I drink alcohol while taking Sildenafil?

It is recommended to limit alcohol consumption, as it can worsen side effects and potentially reduce the effectiveness of Sildenafil.

Is Sildenafil available over the counter?

No, Sildenafil requires a prescription from a licensed healthcare provider.

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