Hepcinat® LP

ledipasivir + sofosbuvir

Brand(s):

• Hepcinat LP

Manufacturer:

• Natco Pharma Ltd.

Disease(s):

• Hepatitis C

Ledipasvir and Sofosbuvir Tablets

What is Ledipasvir and Sofosbuvir?

Ledipasvir and sofosbuvir are antiviral medications designed to stop the hepatitis C virus (HCV) from multiplying within the body. This is a significant step in fighting the infection.

This combination medication is used to treat hepatitis C genotypes 1, 4, 5, and 6. It's approved for use in adults and children who are at least 12 years old and weigh at least 77 pounds (35 kilograms).

Sometimes, doctors prescribe ledipasvir and sofosbuvir along with another medication called ribavirin.

While the information here is comprehensive, it's important to remember that this medication guide doesn't cover every possible use of ledipasvir and sofosbuvir.

Important Information About Ledipasvir and Sofosbuvir

Avoid using ledipasvir and sofosbuvir if you're already taking sofosbuvir tablets (Sovaldi). This is crucial to prevent dangerous drug interactions.

If you've ever had hepatitis B, be aware that ledipasvir and sofosbuvir could cause this condition to reappear or worsen. Regular blood tests to monitor your liver function are essential.

Talking to Your Doctor Before Taking Ledipasvir and Sofosbuvir

You should not use ledipasvir and sofosbuvir if you have an allergy to it or if you are taking sofosbuvir (Sovaldi).

Before starting treatment, let your doctor know if you have:

• A history of hepatitis B
• Liver problems besides hepatitis C
• A history of a liver transplant
• Kidney disease (or if you're on dialysis)
• HIV or AIDS
• A heart rhythm problem for which you take amiodarone (Cordarone, Pacerone)

Important Note about Ribavirin: You should not use ledipasvir and sofosbuvir with ribavirin if you have:

• Severe kidney disease
• A hemoglobin blood cell disorder like sickle-cell anemia or thalassemia
• If you are pregnant, or if you are a man and your sexual partner is pregnant.

While ledipasvir and sofosbuvir isn't expected to harm an unborn baby, it's vital to inform your doctor if you are pregnant or planning a pregnancy. Ribavirin, however, can cause serious birth defects or death in an unborn baby. Strict adherence to pregnancy precautions is paramount when ribavirin is part of the treatment regimen.

• If you are a woman, do not take ribavirin if you are pregnant. If you are a man, do not take ribavirin if your sexual partner is pregnant.
• Use at least two effective forms of birth control to prevent pregnancy while either sexual partner is taking ribavirin. Continue using two forms of birth control for at least six months after treatment ends.
• Report any pregnancy immediately to your doctor.

Taking Ledipasvir and Sofosbuvir

Your doctor will conduct blood tests to ensure ledipasvir and sofosbuvir is safe for you. Always follow the instructions on your prescription label. Don't adjust the dosage without consulting your doctor.

You can take ledipasvir and sofosbuvir with or without food, but consistency is key – take it at the same time daily. Treatment typically lasts 12 to 24 weeks, but your doctor will determine the precise duration.

Regular blood tests are necessary to monitor your liver function. Hepatitis C treatment often involves a combination of medications, so it’s crucial to follow your doctor's instructions precisely. Never stop taking ledipasvir and sofosbuvir suddenly, as this could make your condition more difficult to treat.

If you have a history of hepatitis B, be aware that ledipasvir and sofosbuvir could reactivate the virus. Continued liver function monitoring is essential even after treatment ends.

Store the medication in its original container at room temperature, away from moisture and heat.

Missed Dose

Take the missed dose as soon as you remember, unless it's almost time for your next dose. Don't double up on doses.

Things to Avoid While Taking Ledipasvir and Sofosbuvir

Avoid antacids containing aluminum or magnesium (like Maalox, Mylanta, etc.) within four hours before or after taking ledipasvir and sofosbuvir. This medication doesn't prevent transmission of hepatitis C. Practice safe sex and avoid sharing personal items like razors or toothbrushes.

Possible Side Effects

Seek immediate medical attention if you experience signs of an allergic reaction: hives, difficulty breathing, swelling of the face, lips, tongue, or throat.

If you're also taking amiodarone, contact your doctor immediately if you notice:

• Extreme tiredness
• Unusual weakness
• Confusion or memory problems
• Lightheadedness
• Slowed breathing
• Chest pain, slow heartbeats, weak pulse

Common side effects may include weakness, headache, and fatigue.

Drug Interactions

Many medications can interact with ledipasvir and sofosbuvir. Inform your doctor about all your current medications, especially:

• Amiodarone
• Digoxin (digitalis)
• Other hepatitis C drugs (simeprevir, sofosbuvir)
• Rosuvastatin (Crestor)
• St. John's wort
• HIV/AIDS medications (atazanavir, cobicistat, etc.)
• Seizure medications (carbamazepine, oxcarbazepine, etc.)
• Stomach acid reducers (cimetidine, esomeprazole, etc.)
• Tuberculosis medications (rifabutin, rifampin, rifapentine)

This isn't an exhaustive list. Provide your doctor with a complete list of all medications you are taking, including over-the-counter drugs, vitamins, and herbal supplements.