Questran

cholestyramine

Brand(s):

• Choltran

Manufacturer:

• Ajanta Pharma Limited

Disease(s):

• High Cholesterol / Low-density Lipoprotein / Low Density

Cholestyramine Powder: A Comprehensive Guide

What is Cholestyramine?

Cholestyramine is a medication primarily used to lower high cholesterol levels in the blood. High cholesterol increases your risk of heart disease and atherosclerosis (hardening of the arteries). It works by binding to bile acids in your digestive tract, preventing their reabsorption into the bloodstream. This forces your liver to use cholesterol to make more bile acids, effectively lowering your cholesterol levels. Specifically, cholestyramine is particularly effective at reducing low-density lipoprotein (LDL), often referred to as "bad" cholesterol. Beyond cholesterol management, it's also used to relieve itching associated with bile duct blockages, a complication sometimes seen with gallbladder issues.

Important Considerations Before Taking Cholestyramine

Before starting cholestyramine, it's crucial to discuss it with your doctor. You should not take this medication if you have an allergy to cholestyramine or any blockage in your stomach or intestines.

Inform your doctor about any pre-existing health conditions, including:

• Thyroid disorders
• Diabetes
• Kidney disease
• Liver disease
• Chronic constipation

Cholestyramine falls under FDA pregnancy category C, meaning its effects on unborn babies aren't fully understood. Pregnant or breastfeeding women should consult their doctor before using this medication. Absorption of certain vitamins may be affected while taking cholestyramine, especially during breastfeeding. Cholestyramine may also contain phenylalanine; individuals with phenylketonuria (PKU) should discuss this with their doctor.

How to Take Cholestyramine

Always adhere to your doctor's prescribed dosage. Never adjust the amount or frequency without consulting them. Cholestyramine is often taken multiple times daily (up to six times), usually with meals unless otherwise directed. Mix the powder thoroughly with 2 to 6 ounces of water or another non-carbonated beverage. You can also blend it into certain foods like thin soups, crushed pineapple, or applesauce. Use only the measuring scoop provided with your medication to ensure accurate dosing.

Staying well-hydrated by drinking plenty of fluids will help prevent constipation, a common side effect. Consistent use is essential for optimal results. Remember that cholestyramine is part of a broader approach to managing cholesterol, which usually also includes dietary changes, exercise, and weight management. Regular blood tests might be necessary to monitor your progress. Maintain regular checkups with your doctor.

Missed Dose

Take the missed dose as soon as you remember, unless it's nearly time for your next scheduled dose. Do not double up on doses to compensate for a missed one.

Potential Drug Interactions

Cholestyramine can interfere with the absorption of other medications. This is due to its binding properties affecting the absorption of other medicines in the gut. This interaction can reduce the effectiveness of those medicines. Be aware of potential interactions with:

• Blood thinners (e.g., warfarin)
• Digoxin
• Propranolol
• Diuretics ("water pills")
• Thyroid hormones (e.g., levothyroxine)
• Birth control pills or hormone replacement therapy
• Seizure medications (e.g., phenytoin, phenobarbital)
• Certain antibiotics (e.g., amoxicillin, doxycycline, minocycline, penicillin, tetracycline)

This is not an exhaustive list; other drugs may also interact with cholestyramine. Always inform your doctor or pharmacist about all medications you are taking.

Medication Timing

To minimize drug interactions, avoid taking other medications concurrently with cholestyramine. Wait at least 4 to 6 hours after taking cholestyramine before taking other medications.

Possible Side Effects

Seek immediate medical attention if you experience signs of an allergic reaction: hives, difficulty breathing, swelling of the face, lips, tongue, or throat.

Contact your doctor immediately if you experience serious side effects such as:

• Blood in your urine
• Severe stomach pain
• Persistent constipation
• Shortness of breath
• Black, bloody, or tarry stools
• Easy bruising or bleeding

Less serious side effects may include:

• Mild constipation or diarrhea
• Stomach pain, nausea, loss of appetite, weight changes
• Bloating or gas
• Hiccups or a sour taste in your mouth
• Skin rash or itching
• Tongue irritation
• Rectal itching or irritation
• Muscle or joint pain
• Dizziness, vertigo, ringing in the ears

This is not a complete list. Other side effects may occur.

Storage

Store cholestyramine powder at room temperature, away from moisture and heat.