Combigan®

brimonidine tartate + timolol maleate

Brand(s):

• Combigan

Manufacturer:

• Allergan

Disease(s):

• Ocular Hypertension

Brimonidine and Timolol Ophthalmic: Lower Eye Pressure Safely

What is Brimonidine and Timolol Ophthalmic?

Brimonidine and timolol ophthalmic is a prescription eye drop medication used to treat open-angle glaucoma or ocular hypertension (high pressure inside the eye). It works by reducing the amount of fluid in the eye, which decreases pressure inside the eye.

Warnings

You should not use Brimonidine and Timolol Ophthalmic if you have a history of asthma or chronic obstructive pulmonary disease (COPD), or a serious heart condition such as 'AV block,' severe heart failure, or slow heartbeats that have caused you to faint.

Brimonidine and Timolol Ophthalmic should not be given to a child younger than 2 years old.

Before Taking This Medicine

Before using Brimonidine and Timolol Ophthalmic, tell your doctor if you have any of the following conditions:

• Congestive heart failure, coronary artery disease, history of stroke or blood clot
• High or low blood pressure, circulation problems (such as Raynaud's syndrome)
• Depression
• Diabetes (using Brimonidine and Timolol Ophthalmic may make it harder for you to tell when you have low blood sugar)
• Thyroid disorder
• Any allergies
• Myasthenia gravis
• History of glaucoma or increased pressure inside your eye

Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Timolol ophthalmic can pass into breast milk and may harm a nursing baby. You should not breast-feed while using Brimonidine and Timolol Ophthalmic.

How Should I Take Brimonidine and Timolol Ophthalmic?

Follow all directions on your prescription label and read the medication guide provided by your pharmacist before using Brimonidine and Timolol Ophthalmic.

1. Wash your hands before using the eye drops.
2. Tilt your head back slightly and pull down your lower eyelid to create a small pocket.
3. Hold the dropper above the eye with the tip down. Look up and away from the dropper and squeeze out a drop.
4. Close your eyes for 2 or 3 minutes with your head tipped down, without blinking or squinting. Gently press your finger to the inside corner of the eye for about 1 minute, to keep the liquid from draining into your tear duct.
5. Use only the number of drops your doctor has prescribed.
6. If you use more than one drop, wait about 5 minutes between drops.
7. Wait at least 10 minutes before using any other eye drops your doctor has prescribed.
8. Do not touch the tip of the eye dropper or place it directly on your eye. A contaminated dropper can infect your eye, which could lead to serious vision problems.
9. Do not use the eye drops if the liquid has changed colors or has particles in it. Call your pharmacist for new medicine.
10. Store at room temperature away from moisture and heat. Do not freeze. Keep the bottle tightly closed when not in use.

What Should I Avoid While Taking Brimonidine and Timolol Ophthalmic?

• This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
• Do not use other eye medications unless your doctor tells you to.

Brimonidine and Timolol Ophthalmic Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• Slow or uneven heart rate
• Pounding heartbeats or fluttering in your chest
• Shallow breathing, feeling like you might pass out
• Severe swelling, redness, or discomfort in or around your eye
• Eye pain or increased watering
• Numbness or tingly feeling in your hands or feet

Common side effects of Brimonidine and Timolol Ophthalmic may include:

• Drowsiness, tired feeling
• Mild itching, redness, or irritation of your eyes
• Mild stinging or burning when using the eye drops

What Other Drugs Will Affect Brimonidine and Timolol Ophthalmic?

Using Brimonidine and Timolol Ophthalmic with other drugs that make you sleepy or slow your breathing can increase these effects. Ask your doctor before using Brimonidine and Timolol Ophthalmic with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Brimonidine and Timolol Ophthalmic, especially:

• Digoxin, digitalis
• Reserpine
• An antidepressant--amitriptyline, bupropion, clomipramine, desipramine, doxepin, duloxetine, fluoxetine, imipramine, nortriptyline, paroxetine
• An MAO inhibitor--isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, tranylcypromine
• A beta blocker--atenolol, carvedilol, labetalol, metoprolol, nadolol, nebivolol, propranolol, sotalol, and others
• Heart or blood pressure medicine--amlodipine, diltiazem