Depakote

divalproex

Brand(s):

• Divaa Valance Desvaler Depakote

Manufacturer:

• Intas Pharmaceuticals Ltd. / Nicholas Piramal India Ltd. / Ranbaxy Laboratories Ltd. / Sanofi-Synthelabo Pharma India Ltd.

Disease(s):

• Epilepsy / Bipolar Disorder / Migraine / Headache

Known as:

• Depa / Depacon / Depakene / Depakote / Deproic / Mendatrex / Stavzor

Divalproex Sodium Delayed-Release Tablets

What is Divalproex Sodium?

Divalproex sodium is a medication primarily used to control seizures in individuals with certain types of epilepsy. Beyond epilepsy, it's also prescribed to manage bipolar mania (the periods of intense energy and mood swings associated with bipolar disorder) and to prevent migraine headaches. It works by affecting the balance of certain chemicals in the brain that are involved in seizure activity and mood regulation.

Important Considerations Before Taking Divalproex Sodium

Before starting divalproex sodium, it's crucial to inform your healthcare provider about your complete medical history. This includes, but isn't limited to:

• Any blood disorders
• Existing brain damage or diseases
• Kidney problems
• Liver disease
• Low levels of blood proteins
• A history of suicidal thoughts, plans, or attempts, either personally or within your family
• Urea cycle disorder (UCD)
• Known allergies to divalproex sodium, other medications, foods, dyes, or preservatives
• Pregnancy or plans to become pregnant (this medication can cause birth defects)
• Breastfeeding (it's passed into breast milk)

Your doctor will assess your overall health and determine if divalproex sodium is the right choice for you, and if so, the appropriate dosage.

How to Take Divalproex Sodium

Divalproex sodium tablets should be swallowed whole with water, as directed by your doctor or pharmacist. Do not crush or chew the tablets. If stomach upset occurs, consider taking the medication with food or milk. Maintain a regular dosing schedule—don't skip doses or take more than prescribed. Children require special considerations, so always consult their pediatrician before administering this medication.

Overdose: In case of an overdose, immediately seek emergency medical assistance or contact a poison control center.

Personal Use Only: This medication is prescribed specifically for you. Do not share it with others.

Missed Dose

If you miss a dose, take it as soon as you remember, unless it's almost time for your next dose. Never double up on doses to compensate for a missed one.

Potential Drug Interactions

Divalproex sodium can interact with various other medications. It's crucial to provide your doctor with a comprehensive list of all medications you're currently taking, including over-the-counter drugs, herbal remedies, and supplements. Some notable interactions include:

• Aspirin
• Barbiturates (e.g., phenobarbital)
• Diazepam
• Isoniazid
• Medications for depression, anxiety, or psychosis
• Anticoagulants (blood thinners) like warfarin
• Meropenem
• Other anticonvulsant (seizure) medications
• Rifampin
• Tolbutamide
• Zidovudine

This list isn't exhaustive, so transparency with your doctor regarding all substances you consume is vital. Alcohol can also interact negatively with divalproex sodium, enhancing drowsiness and dizziness.

Monitoring While Taking Divalproex Sodium

Regular check-ups with your doctor are essential to monitor your progress and adjust your treatment as needed. If you're taking this for epilepsy, abruptly stopping can significantly increase your risk of seizures. Always carry medical identification indicating your condition and medication list.

Common side effects: Drowsiness, dizziness, and blurred vision are possible. Avoid driving or operating machinery until you know how the medication affects you. To reduce dizziness or fainting, change positions slowly.

Blood Problems: Divalproex sodium can affect blood clotting, increasing the risk of bleeding and bruising. This is especially important to consider for dental procedures. Practice gentle oral hygiene.

Sun Sensitivity: The medication can increase sun sensitivity. Protect yourself with clothing, sunscreen, and avoid tanning beds.

Suicidal Thoughts: This medicine may increase the risk of suicidal thoughts. Closely monitor your mood and report any worsening to your doctor immediately.

Possible Side Effects

Report to your doctor immediately if you experience:

• Allergic reactions (rash, itching, hives, swelling)
• Changes in seizure frequency or severity
• Double vision or uncontrolled eye movements
• Nausea and vomiting
• Skin reactions (redness, blistering, peeling)
• Severe stomach pain
• Tremors
• Unusual bleeding or bruising
• Swelling
• Extreme fatigue
• Worsening mood, suicidal thoughts
• Jaundice (yellowing of skin or eyes)

Side effects that usually don't require immediate medical attention (but should be reported if they persist or are bothersome):

• Menstrual cycle changes
• Diarrhea or constipation
• Headaches
• Bladder control problems
• Hair loss or growth changes
• Appetite changes
• Weight changes

This is not an exhaustive list of side effects. Consult your doctor for any concerns.

Storage

Keep divalproex sodium out of reach of children. Store at room temperature (15-30°C or 59-86°F) in a tightly closed container. Discard any unused medication after the expiration date.