Entresto

sacubutril + valsartan

Brand(s):

• Vymada

Manufacturer:

• Novartis Pharmaceuticals Corp

Disease(s):

• Hypertension

Sacubitril and Valsartan Tablets: A Comprehensive Guide

What is Sacubitril and Valsartan?

Sacubitril and valsartan is a combination medication primarily used to treat chronic heart failure. It's a powerful one-two punch combining two different types of blood pressure medications to achieve better results than either could alone. Let's break down each component:

Sacubitril: This is a neprilysin inhibitor. Neprilysin is an enzyme that breaks down certain beneficial proteins in your body. By blocking neprilysin, sacubitril increases the levels of these proteins, which help to relax and widen blood vessels (vasodilation). This improved blood flow leads to lower blood pressure and reduced strain on the heart. Think of it as giving your heart a bit of a break.

Valsartan: This is an angiotensin II receptor blocker (ARB). Angiotensin II is a hormone that causes blood vessels to narrow, increasing blood pressure. Valsartan blocks the action of angiotensin II, preventing blood vessels from constricting and further lowering blood pressure. It complements sacubitril's action by providing another avenue for blood pressure control.

Together, sacubitril and valsartan work synergistically to reduce the risk of hospitalization and death in patients with chronic heart failure. This combination therapy is often used alongside other heart medications for optimal results.

While primarily used for chronic heart failure, it might have other uses not covered here. Always consult your healthcare professional for the most accurate and current information.

Crucial Information About Sacubitril and Valsartan

Pregnancy is a major contraindication. Do not use this medication if you are pregnant, or if you plan to become pregnant. If you become pregnant while taking this medicine, stop immediately and contact your doctor. Sacubitril and valsartan can cause serious harm or even death to the developing fetus, especially during the second and third trimesters.

Individuals with diabetes should avoid using sacubitril and valsartan concurrently with medications containing aliskiren (e.g., Amturnide, Tekturna, Tekamlo, Valturna).

Before You Start Taking Sacubitril and Valsartan: Talk to Your Doctor

Certain conditions and medications make this drug unsuitable. You should not use this medication if:

• You have an allergy to sacubitril, valsartan (Diovan), or other blood pressure medications, such as ACE inhibitors or ARBs.
• You have taken an ACE inhibitor within the last 36 hours.

If you have diabetes, avoid taking sacubitril and valsartan with aliskiren, particularly if you also have kidney disease. This combination could significantly impact your kidney function.

Inform your doctor if you have any of the following:

• Liver disease
• Diabetes
• A low-salt diet
• Dehydration

Again, do not use if you are pregnant or might become pregnant. Reliable birth control is essential while using this medicine.

Breastfeeding is not advised while on this medication as it's unclear whether sacubitril and valsartan passes into breast milk and could potentially harm a nursing infant.

How to Take Sacubitril and Valsartan

Always follow your doctor's instructions precisely. Your dosage may be adjusted over time to maximize effectiveness. Never change your dosage without consulting your doctor.

This medication can be taken with or without food. Maintain a consistent daily schedule for optimal medication levels. Your blood pressure and kidney function will be regularly monitored.

Store your medication in its original container, away from moisture and excessive heat.

Missed Dose?

If you miss a dose, take it as soon as you remember, unless it's almost time for your next dose. Never double up on doses.

Things to Avoid While on Sacubitril and Valsartan

Avoid sudden changes in position (standing up too quickly) to minimize dizziness. Get up slowly.

Unless specifically directed by your doctor, do not use potassium supplements or salt substitutes while taking this medication.

Limit alcohol consumption. Alcohol can lower blood pressure further, potentially increasing side effects.

Potential Side Effects of Sacubitril and Valsartan

Seek immediate medical attention for signs of an allergic reaction: hives, difficulty breathing, swelling of the face, lips, tongue, or throat. Individuals of African-American descent may have a higher risk of allergic reactions.

Contact your doctor immediately if you experience:

• Lightheadedness or near-fainting
• Extreme fatigue
• High potassium levels (slow heart rate, weak pulse, muscle weakness)
• Kidney problems (reduced urination, painful urination, swelling in feet or ankles, fatigue, shortness of breath)

Common side effects include dizziness and cough.

This is not an exhaustive list of potential side effects. Consult your doctor or pharmacist for more comprehensive information.

Interactions with Other Medications

Always inform your doctor of all medications you are currently taking, including over-the-counter drugs, supplements, and herbal remedies, especially:

• Aliskiren
• Lithium
• Other heart or blood pressure medications
• Diuretics ("water pills")
• Potassium supplements or medications containing potassium
• NSAIDs (nonsteroidal anti-inflammatory drugs) such as ibuprofen, naproxen, aspirin, etc.

This is not a complete list of potential interactions. Many drugs can interact with sacubitril and valsartan; always seek your doctor's advice about medication combinations.