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Naproxen Sodium: Your Comprehensive Guide to Pain Relief

Naproxen sodium is a widely used non-steroidal anti-inflammatory drug (NSAID) that provides effective relief from pain, inflammation, and stiffness. This comprehensive guide offers essential information about this medication to help you understand its uses, dosage, precautions, and potential side effects.

Common Uses of Naproxen Sodium

Naproxen sodium is primarily prescribed to manage conditions characterized by pain and inflammation, including:

  • Osteoarthritis: Reduces joint pain and stiffness associated with osteoarthritis.
  • Rheumatoid Arthritis: Alleviates inflammation and pain in rheumatoid arthritis.
  • Psoriatic Arthritis: Helps manage joint pain and inflammation related to psoriatic arthritis.
  • Ankylosing Spondylitis: Eases stiffness and pain in the spine and other joints.
  • Gout: Provides relief from acute gout attacks by reducing inflammation and pain in the affected joint.
  • Bursitis and Tendonitis: Reduces inflammation and pain in bursae and tendons.
  • Menstrual Cramps (Dysmenorrhea): Alleviates pain associated with menstrual periods.
  • Mild to Moderate Pain: Can be used for short-term relief of pain from headaches, muscle aches, toothaches, and post-surgical pain.

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Dosage and Administration

Follow these guidelines for the safe and effective use of Naproxen Sodium:

  • Administration: Take Naproxen Sodium orally with a full glass of water. It can be taken with or without food. If you experience stomach upset, taking it with food may help.
  • Form: Do not cut, crush, or chew the tablet. Swallow it whole.
  • Frequency: Take the medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or take it more frequently than directed.
  • Consistency: It may take several days or weeks to experience the full benefits of the medication. Continue taking it as prescribed, even if you feel better.
  • Consultation: Always consult your doctor or pharmacist for personalized dosage instructions based on your specific condition and medical history.

Important Precautions

Before taking Naproxen Sodium, consider the following precautions:

  • Allergies: Inform your doctor or pharmacist if you are allergic to naproxen, aspirin, other NSAIDs (such as ibuprofen), or any other substances.
  • Medical History: Disclose your complete medical history, especially if you have or have had:
    • Asthma (especially if triggered by aspirin or NSAIDs)
    • Bleeding problems
    • Heart disease
    • High blood pressure
    • Kidney disease
    • Liver disease
    • Stomach or intestinal problems (such as ulcers, bleeding)
  • Sodium and Lithium: Naproxen can affect sodium and lithium levels. Use caution if you are taking lithium supplements.
  • Alcohol and Smoking: Avoid alcohol consumption and smoking while taking Naproxen Sodium, as they can increase the risk of stomach bleeding.
  • Elderly Patients: Older adults may be more sensitive to the side effects of this medication, particularly stomach bleeding and kidney problems.
  • Pregnancy: Naproxen should be used during pregnancy only when clearly necessary and after discussing the risks and benefits with your doctor, especially during the third trimester. Naproxen may cause premature closure of the ductus arteriosus, a blood vessel in the baby's heart.
  • Breastfeeding: Consult your doctor before breastfeeding while taking Naproxen Sodium.
  • Skin Absorption: Pregnant women or those who may become pregnant should avoid handling this medication due to potential skin absorption.

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Contraindications

Naproxen Sodium is not suitable for everyone. It is contraindicated in the following conditions:

  • Hypersensitivity: Patients with known hypersensitivity or allergic reactions to naproxen or other NSAIDs.
  • Sodium-Sensitive Hypertension: Individuals with sodium-sensitive hypertension should avoid this medication.
  • History of Asthma: Patients who have experienced asthma, hives, or allergic-type reactions after taking aspirin or other NSAIDs.
  • CABG Surgery: Naproxen should not be used before or after coronary artery bypass graft (CABG) surgery.

Potential Side Effects

Naproxen Sodium can cause side effects, although not everyone experiences them. Common side effects include:

  • Gastrointestinal: Heartburn, nausea, stomach pain, constipation, diarrhea.
  • Central Nervous System: Dizziness, drowsiness, headache.
  • Other: Dry mouth, increased thirst, swelling of ankles/feet, ringing in the ears.

Serious side effects are rare but require immediate medical attention:

  • Allergic Reactions: Rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, trouble breathing.
  • Cardiovascular: Chest pain, shortness of breath, weakness on one side of the body, slurred speech.
  • Gastrointestinal: Black or tarry stools, persistent stomach pain, vomiting blood or material that looks like coffee grounds.
  • Liver Problems: Dark urine, yellowing of the skin or eyes.
  • Kidney Problems: Change in the amount of urine, swelling, fatigue.

If you experience any unusual or severe side effects, contact your doctor or pharmacist immediately.

Drug Interactions

Before starting Naproxen Sodium, inform your doctor and pharmacist about all medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements. Significant interactions can occur with:

  • Other NSAIDs: Concurrent use with other NSAIDs, such as ibuprofen (Advil, Motrin) or aspirin, increases the risk of stomach bleeding and ulcers.
  • Anticoagulants: Naproxen can enhance the effects of blood thinners like warfarin (Coumadin), increasing the risk of bleeding.
  • Corticosteroids: Taking naproxen with corticosteroids such as prednisone may increase the risk of gastrointestinal ulcers and bleeding.
  • Antihypertensives: Naproxen can reduce the effectiveness of blood pressure medications.
  • Lithium: Naproxen can increase lithium levels in the blood, potentially leading to toxicity.
  • Methotrexate: Naproxen can increase methotrexate levels, potentially leading to toxicity.
  • Selective Serotonin Reuptake Inhibitors (SSRIs): Combining naproxen with SSRIs like fluoxetine (Prozac) or sertraline (Zoloft) may increase the risk of gastrointestinal bleeding.

Managing a Missed Dose

If you miss a dose of Naproxen Sodium, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

Recognizing and Handling Overdose

An overdose of Naproxen Sodium can be serious. Seek immediate medical attention if you suspect an overdose. Symptoms of an overdose may include:

  • Nausea
  • Vomiting
  • Stomach pain
  • Drowsiness
  • Dizziness
  • Seizures
  • Difficulty breathing
  • Loss of consciousness

Proper Storage Instructions

Store Naproxen Sodium properly to maintain its effectiveness and safety:

  • Store at room temperature, between 68-77°F (20-25°C).
  • Protect from light and moisture.
  • Do not store in the bathroom.
  • Keep out of reach of children and pets.
  • Dispose of unused medication properly, following local regulations.

FAQ About Naproxen Sodium

Can I take Naproxen Sodium on an empty stomach?
Yes, you can take it on an empty stomach, but taking it with food may help reduce stomach upset.
How long does it take for Naproxen Sodium to work?
It can take up to two weeks to feel the full effect. For acute pain like menstrual cramps, it should work within an hour.
Is Naproxen Sodium safe for long-term use?
Long-term use should be under the guidance of a doctor, as it can increase the risk of side effects.
Can I drink alcohol while taking Naproxen Sodium?
It is best to avoid alcohol, as it can increase the risk of stomach bleeding.
Can I take Naproxen Sodium with other pain relievers?
Avoid taking it with other NSAIDs like ibuprofen or aspirin without consulting your doctor.

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