Pms-pioglitazone (other name Actoplus Met)

Diabetes

Pms-pioglitazone (other name Actoplus Met) 500mg

Package	Per Pill	Special Price
360 pills Free Express Delivery	$0.95	~~$515~~ -34% Only $343
270 pills Free Regular Delivery	$0.97	~~$387~~ -33% Only $261
180 pills	$0.99	~~$258~~ -31% Only $179
30 pills	$1.43	~~$43~~ --0% Only $43
60 pills	$1.17	~~$86~~ -19% Only $70
90 pills	$1.09	~~$129~~ -24% Only $98
120 pills	$1.04	Only $125

Actoplus Met (Pioglitazone/Metformin)

Uses

Actoplus Met is a combination medication containing pioglitazone and metformin, prescribed for the management of type 2 diabetes mellitus. It helps control blood sugar levels when used in conjunction with a proper diet and exercise regimen. It can be used as a standalone treatment or in combination with other antidiabetic medications to achieve optimal glycemic control.

Dosage and Administration

Always follow your doctor's instructions when using Actoplus Met. The dosage will depend on your individual condition and response to treatment. Consult the prescription label for precise dosing information.

Important Instructions:

Actoplus Met should be taken orally with meals to minimize gastrointestinal discomfort.
Maintain a consistent daily schedule to ensure optimal effectiveness. Taking the medication at the same time(s) each day will help you remember.
Continue taking Actoplus Met as prescribed, even if you feel well. Do not skip doses.
An additional patient information leaflet is provided with Actoplus Met. Consult your pharmacist if you have any questions regarding this information.

Drug Class and Mechanism of Action

Actoplus Met is classified as a combination of biguanide (metformin) and thiazolidinedione (pioglitazone) antidiabetic agents. It functions through multiple mechanisms:

Metformin reduces glucose production in the liver and decreases glucose absorption in the intestines.
Pioglitazone enhances the body's sensitivity to insulin, enabling more efficient glucose utilization.

What to do if you Missed a Dose

If you forget to take a dose of Actoplus Met, take it as soon as you remember. However, if it is nearing the time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.

Storage Instructions

Store Actoplus Met at room temperature (77 degrees F or 25 degrees C) in a tightly sealed container, away from heat, moisture, and direct light. Brief storage between 59 and 86 degrees F (15 and 30 degrees C) is acceptable.

Contraindications and Precautions

Do NOT use Actoplus Met if:

You have a known allergy to any of the ingredients in Actoplus Met.
You have type 1 diabetes.
You suffer from moderate to severe heart failure.
You have a severe infection, low blood oxygen levels, kidney or liver problems, or high blood ketone or acid levels (e.g., diabetic ketoacidosis), or are severely dehydrated.
You have experienced a stroke or recent heart attack, or are in shock.
You are 80 years of age or older and have not undergone a kidney function test.
You are scheduled for surgery or certain lab procedures.
You have a history of liver problems, including jaundice (yellowing of the skin or eyes), during treatment with troglitazone (a similar medicine).

Consult your healthcare provider immediately if any of these conditions apply to you.

Medical Conditions and Interactions:

Certain medical conditions may interact with Actoplus Met. Inform your doctor or pharmacist about any existing medical conditions, especially if any of the following apply:

Pregnancy, planned pregnancy, or breastfeeding.
Use of any prescription or nonprescription medication, herbal supplement, or dietary supplement.
Allergies to medications, foods, or other substances.
History of heart problems (e.g., heart failure), abnormal liver function tests, lung or breathing problems, thyroid issues, stomach or bowel problems (e.g., paralysis, blockage), adrenal or pituitary problems, eye or vision problems (e.g., macular degeneration), bladder cancer, or lactic acidosis.
Fluid retention or swelling problems, vomiting, diarrhea, poor health or nutrition, low blood calcium or vitamin B12 levels, or anemia, or if you are dehydrated.
Infection, fever, recent injury, or moderate to severe burns.
History of bone fracture, weak bones (e.g., osteoporosis), or low calcium intake.
Alcohol consumption or a history of alcohol abuse.
Upcoming surgery or certain lab procedures.
Use of a beta-blocker (e.g., propranolol).

Drug Interactions:

Some medications may interact with Actoplus Met. Inform your healthcare provider about all other medications you are taking, particularly the following:

Amiloride, cimetidine, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, or vancomycin, as they may increase the risk of Actoplus Met side effects.
Calcium channel blockers (e.g., nifedipine), corticosteroids (e.g., prednisone), diuretics (e.g., furosemide, hydrochlorothiazide), estrogen, hormonal contraceptives (e.g., birth control pills), insulin, isoniazid, nicotinic acid, oral antidiabetics (e.g., glipizide), phenothiazines (e.g., chlorpromazine), phenytoin, sympathomimetics (e.g., albuterol, pseudoephedrine), or thyroid hormones (e.g., levothyroxine), as the risk of high or low blood sugar may be increased.
Gemfibrozil, as it may increase the risk of Actoplus Met side effects.
Rifampin, as it may decrease Actoplus Met effectiveness, potentially leading to high blood sugar.
Anticoagulants (e.g., warfarin), as their effectiveness may be decreased, or the risk of their side effects may be increased by Actoplus Met.

Possible Side Effects

All medications can cause side effects, but many individuals experience none or only minor side effects. Contact your doctor if any of the following COMMON side effects persist or become bothersome:

Cold-like symptoms
Diarrhea
Headache
Indigestion
Mild weight gain
Nausea
Stomach upset

Seek immediate medical attention if any of these SERIOUS side effects occur:

Severe allergic reactions (rash, hives, itching, difficulty breathing, tightness in the chest, swelling of the mouth, face, lips, or tongue)
Blurred vision or other vision changes
Bone pain
Chest pain or discomfort
Dark urine
Difficult or painful urination
Dizziness or lightheadedness
Fainting
Fast or difficult breathing
Feeling unusually cold
General feeling of being unwell
Muscle pain or weakness
Pale stools
Persistent loss of appetite
Severe or persistent headache, nausea, or vomiting
Shortness of breath
Slow or irregular heartbeat
Sudden unexplained weight gain
Swelling of the hands, ankles, or feet
Unusual stomach pain or discomfort
Unusual drowsiness
Unusual tiredness or weakness
Yellowing of the eyes or skin

Additional Information

Consult your doctor, pharmacist, or other healthcare provider if you have any questions regarding Actoplus Met.

Actoplus Met is prescribed solely for the patient for whom it is intended. Do not share it with others.
Consult your doctor if your symptoms do not improve or if they worsen.
If using Actoplus Met for an extended period, obtain refills before your supply runs out.

FAQ

Can I drink alcohol while taking Actoplus Met?

Alcohol consumption can affect blood sugar levels and may increase the risk of certain side effects, such as lactic acidosis. It is best to discuss alcohol consumption with your doctor while taking Actoplus Met.

Will Actoplus Met cause weight gain?

Mild weight gain is a possible side effect. Report any significant or sudden weight gain to your doctor.

How often should I monitor my blood sugar levels?

Follow your doctor's recommendations for blood sugar monitoring. Regular monitoring is essential for managing your diabetes effectively.

What should I do if I experience symptoms of low blood sugar (hypoglycemia)?

Symptoms of low blood sugar include sweating, shaking, dizziness, hunger, and confusion. If you experience these symptoms, consume a quick source of sugar, such as glucose tablets, juice, or hard candy, and then consult your doctor.

Can Actoplus Met be used during pregnancy or breastfeeding?

Discuss the use of Actoplus Met during pregnancy or breastfeeding with your doctor. They will assess the potential risks and benefits for you and your baby.