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Rebilex-isr (other name Aciphex)

Rebilex-isr (other name Aciphex) 20mg

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Aciphex (Rabeprazole): Comprehensive Medication Guide

What is Aciphex?

Aciphex, containing the active ingredient rabeprazole, is a proton pump inhibitor (PPI) used to reduce the amount of acid produced in the stomach. It belongs to a class of drugs that work by blocking the enzyme (H+, K+-ATPase) responsible for the final step of acid production. This action helps to relieve symptoms and promote healing in conditions caused by excess stomach acid.

Indications and Uses

Aciphex is prescribed for the treatment and management of various gastrointestinal conditions, including:

  • Peptic Ulcers: Healing and maintenance of duodenal and gastric ulcers.
  • Gastroesophageal Reflux Disease (GERD): Relief of symptoms such as heartburn and acid regurgitation, and healing of erosive esophagitis.
  • Zollinger-Ellison Syndrome: Management of excessive acid production in this rare condition.
  • Helicobacter pylori Eradication: Used in combination with antibiotics to eliminate H. pylori infection, a common cause of ulcers.

Dosage and Administration

The correct dosage of Aciphex will be determined by your healthcare provider based on your specific condition and medical history. Follow these general guidelines:

  • General Dosage: The typical dose is 20 mg taken once daily, usually in the morning.
  • Duodenal Ulcer: 20 mg once daily for 4-6 weeks.
  • Erosive Esophagitis: 20 mg once daily for up to 8 weeks. Maintenance therapy may be considered after healing.
  • H. pylori Eradication: Aciphex is typically used as part of a combination therapy (e.g., with antibiotics) for 7-14 days.

Important Instructions:

  • Take Aciphex exactly as prescribed. Do not change the dose or duration of treatment without consulting your doctor.
  • Swallow the tablets whole with a glass of water. Do not crush, chew, or split them.
  • Aciphex can be taken with or without food.

Precautions and Warnings

Before taking Aciphex, inform your doctor about the following:

  • Liver Disease: If you have a history of liver problems, your doctor may need to adjust your dose.
  • Stomach Cancer: Aciphex can mask symptoms of stomach cancer, so it's essential to rule out this condition before starting treatment.
  • Pregnancy and Breastfeeding: Discuss the risks and benefits of Aciphex with your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
  • Other Medications: Provide a complete list of all medications, supplements, and herbal products you are taking.
  • Long-term Use: Prolonged use of PPIs like Aciphex may be associated with an increased risk of certain side effects, such as bone fractures and vitamin B12 deficiency. Your doctor may recommend monitoring and supplementation if needed.
  • Children: Aciphex is generally not recommended for use in children.

Contraindications

Aciphex is contraindicated in individuals with:

  • Known hypersensitivity or allergy to rabeprazole or any other proton pump inhibitors (PPIs) such as omeprazole, lansoprazole, pantoprazole, or esomeprazole.
  • Pregnancy and breastfeeding.

Possible Side Effects

While Aciphex is generally well-tolerated, some individuals may experience side effects. Common side effects may include:

  • Headache
  • Diarrhea
  • Nausea
  • Abdominal pain
  • Flatulence
  • Constipation
  • Dry mouth
  • Insomnia
  • Nervousness
  • Rash or itching

Serious Side Effects:

Seek immediate medical attention if you experience any of the following serious side effects:

  • Severe allergic reaction (hives, rash, swelling of the face, tongue, or throat, difficulty breathing)
  • Severe stomach pain
  • Bloody or black stools
  • Unexplained weight loss
  • Seizures

Drug Interactions

Aciphex can interact with several medications, potentially altering their effects. Significant interactions include:

  • Ketoconazole and Itraconazole: Aciphex can reduce the absorption of these antifungal medications, decreasing their effectiveness.
  • Digoxin: Aciphex can increase the absorption of digoxin, potentially leading to toxicity.
  • Warfarin: Aciphex may increase the risk of bleeding in patients taking warfarin.
  • Methotrexate: Concomitant use with methotrexate may increase methotrexate levels.
  • Clopidogrel: Aciphex may reduce the effectiveness of clopidogrel.

Always inform your doctor and pharmacist about all the medications you are taking to avoid potential drug interactions.

Missed Dose

If you miss a dose of Aciphex, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

Overdose

Symptoms of Aciphex overdose are not well-defined. If you suspect an overdose, seek immediate medical attention or contact a poison control center.

Storage

Store Aciphex at room temperature between 59-77°F (15-25°C) away from light, moisture, children, and pets.

FAQ about Aciphex

  • Can I take Aciphex with other medications?
    Discuss all medications with your doctor to avoid potential interactions.
  • How long does it take for Aciphex to work?
    Aciphex starts to reduce stomach acid within an hour, with maximum effect in 2-4 hours.
  • Can I crush or chew Aciphex tablets?
    No, swallow the tablets whole with water.
  • What should I do if I experience side effects?
    Contact your doctor if side effects are severe or persistent. Seek immediate medical attention for serious side effects.
  • Is Aciphex safe during pregnancy?
    Discuss the risks and benefits with your doctor if you are pregnant or planning to become pregnant.

Disclaimer: The information provided here is for general knowledge purposes only and does not constitute medical advice. It is essential to consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.

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