Seroxat (other name Paxil)

Paroxetine: Information for Safe and Effective Use

What is Paroxetine?

Paroxetine is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It is used to treat depression, obsessive-compulsive disorder (OCD), panic disorder, social anxiety disorder (social phobia), post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD). Paroxetine works by helping to restore the balance of serotonin, a natural substance in the brain, which helps improve certain mood problems.

Important Information Before Taking Paroxetine

Medical Conditions to Disclose

Before you start taking paroxetine, it is crucial to inform your healthcare provider about any pre-existing medical conditions you have. This information helps ensure your safety and the effectiveness of the medication. Please tell your provider if you have:

• Bipolar disorder or a family history of bipolar disorder
• Heart disease
• Kidney or liver disease
• Are receiving electroconvulsive therapy
• Seizures (convulsions)
• Suicidal thoughts or a previous suicide attempt
• Any unusual or allergic reaction to paroxetine, other medicines, foods, dyes, or preservatives
• Are pregnant or trying to get pregnant
• Are breast-feeding

How to Use Paroxetine

Dosage and Administration

Take paroxetine exactly as prescribed by your doctor. It is available in tablet and liquid form. Follow the directions on the prescription label carefully.

• For the liquid form, shake well before using.
• Use a specially marked spoon or container to measure your medicine. Household spoons are not accurate.
• You can take it with or without food.
• Take your medicine at regular intervals.
• Do not take your medicine more often than directed.
• Do not stop taking the medication except on your doctor's advice.

Use in Children

Consult your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage

If you think you have taken too much of this medicine, contact a poison control center or emergency room at once.

What to Do if You Miss a Dose

If you miss a dose, take it as soon as you can. If it is less than four hours until your next dose, take only that dose and skip the missed dose. Do not take double or extra doses.

Possible Interactions with Other Medications

Medications to Avoid

Do not take this medicine with any of the following medications:

• Certain diet drugs like dexfenfluramine, fenfluramine, phentermine
• MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
• Medicines similar to paroxetine like fluoxetine, sertraline, citalopram
• Phenothiazines like thioridazine
• Pimozide
• Procarbazine
• St. John's wort
• Tryptophan

Other Medications That May Interact

This medicine may also interact with the following medications:

• Aspirin and aspirin-like drugs
• Cimetidine
• Digoxin
• Fosamprenavir
• Linezolid
• Medicines for depression, anxiety, or psychotic disturbances
• Medicines for migraine headache like almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan
• Medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin
• NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
• Phenobarbital
• Phenytoin
• Procyclidine
• Ritonavir
• Theophylline

Important Note

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also, tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What to Watch For While Using Paroxetine

Visit your doctor or health care professional for regular checks on your progress. Continue to take your medicine even if you do not immediately feel better. It can take several weeks before you feel the full effect of this medicine.

Monitoring Mood Changes

Patients and their families should watch out for depression or thoughts of suicide that get worse. Also, watch out for sudden or severe changes in feelings such as feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, overly excited and hyperactive, or not being able to sleep. If this happens, especially at the beginning of antidepressant treatment or after a change in dose, call your health care professional.

Discontinuation of Treatment

If you have been taking this medicine regularly for some time, do not suddenly stop taking it. You must gradually reduce the dose or your symptoms may get worse. Ask your doctor or health care professional for advice.

Driving and Alcohol Consumption

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can increase or decrease the effects of this medicine. Avoid alcoholic drinks.

Other Precautions

Do not treat yourself for coughs, colds, or allergies without asking your doctor or health care professional for advice. Some ingredients can increase possible side effects.

Dry Mouth

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water will help.

Possible Side Effects of Paroxetine

Side Effects Requiring Immediate Medical Attention

Report the following side effects to your doctor or health care professional as soon as possible:

• Allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
• Black or bloody stools, blood in the urine or vomit
• Fast, irregular heartbeat
• Hallucination, loss of contact with reality
• Painful or prolonged erection (men)
• Seizures
• Suicidal thoughts or other mood changes
• Trouble passing urine or change in the amount of urine
• Unusual bleeding or bruising
• Unusually weak or tired
• Vomiting

Common Side Effects

The following side effects usually do not require medical attention. Report them to your doctor or health care professional if they continue or are bothersome:

• Change in appetite, weight
• Change in sex drive or performance
• Constipation or diarrhea
• Difficulty sleeping
• Drowsiness
• Headache
• Increased sweating
• Muscle pain or weakness
• Tremors

How to Store Paroxetine

• Keep out of the reach of children.
• Store at or below 25 degrees C (77 degrees F). Keep container tightly closed.
• Throw away any unused medicine after the expiration date.

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Paroxetine FAQ

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